{"id":6322,"date":"2019-08-27T04:42:29","date_gmt":"2019-08-27T11:42:29","guid":{"rendered":"https:\/\/www.liveviewgps.com\/blog\/?p=6322"},"modified":"2025-09-16T13:24:06","modified_gmt":"2025-09-16T20:24:06","slug":"blood-test-alzheimers-94-accuracy","status":"publish","type":"post","link":"https:\/\/www.liveviewgps.com\/blog\/blood-test-alzheimers-94-accuracy\/","title":{"rendered":"New Blood Test for Alzheimers Has 94% Accuracy"},"content":{"rendered":"

A newer blood test for detecting brain changes indicative of early Alzheimer’s disease (AD) is becoming more realistic and could change everything for the field.<\/p>\n

Researchers of a study published in Neurology, found that assessing the \u03b2-amyloid (A\u03b2) 42 and A\u03b240 ratio in blood with the use of a high-accuracy evaluation is 94 percent accurate in brain amyloidosis diagnosis<\/a>, using the reference standards CSF phosphorylated (p-tau) 181\/A\u03b242 or amyloid PET.<\/p>\n

According to senior investigator and St. Louis’s Washington University School of Medicine’s professor of neurology, Randall J. Bateman, MD<\/a>, at the moment, individuals are screened for clinical trials with expensive and time-consuming brain scans and it takes years to enroll people.<\/p>\n

He added, that with a blood test, each month they could possibly screen thousands of individuals, meaning they could enroll individuals in clinical trials more efficiently, helping them find treatments quicker. And that could have a huge affect on the expense of AD and the suffering it causes to individuals.<\/p>\n

<\/p>\n

Simple Screening Tool<\/strong><\/p>\n

Using a liquid chromatography-mass spectrometry and immunoprecipitation evaluation, the researchers assessed CSF samples and A\u03b242\/A\u03b240 in plasma they gathered inside the 18 months of an amyloid PET scan from 158 older individuals mostly cognitively normal.<\/p>\n

The combination of apolipoprotein (APOE) \u03b54 status, age and A\u03b242\/A\u03b240 had “extremely high” (AUC, 0.94; 95% CI, 0.90 – 0.97) association with amyloid PET. This suggested the plasma A\u03b242\/A\u03b240 could serve as a tool to screen individuals who have a higher chance of AD dementia, according to the researchers.<\/p>\n

Also, those with negative amyloid PET scan, but a positive plasma A\u03b242\/A\u03b240 have a 15-fold greater chance <\/a>of changing to amyloid PET-positive (P = .01).<\/p>\n

The plasma A\u03b242\/A\u03b240 analysis sensitivity to amyloid PET-negative people converting to amyloid PET-positive indicates plasma A\u03b242\/A\u03b240 must become positive sooner than the set amyloid PET threshold the study uses.<\/p>\n

So, a positive plasma A\u03b242\/A\u03b240 combined with a negative amyloid PET scan might constitute early amyloidosis instead of a false-positive result in certain people.<\/p>\n

The study builds on the researchers’ earlier work that Medscape Medical News reported.<\/a><\/p>\n

Plasma A\u03b242\/A\u03b240 assay’s most immediate use is brain amyloidosis screening in potential individuals for AD drug trials, noted investigators.<\/p>\n

The plasma A\u03b242\/A\u03b240 screening would decrease how many confirmatory tests there are significantly like amyloid PET or CSF biomarkers which are required for selecting people with brain amyloidosis, particularly in prevention trial cases, which recruit people who are cognitively normal and have a fairly low brain amyloidosis rate.<\/p>\n

Researchers approximate that for a prevention trial like the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) Study, plasma A\u03b242\/A\u03b240\u00a0 pre-screening would cause a 62 percent decrease<\/a> in amyloid PET scans, resulting in significantly reduced costs and time for recruitment.<\/p>\n

The study was supported by the Alzheimer’s Association, part of the National Institutes of Health (NIH), the National Institute on Aging, Eli Lilly Co\/Avid Radiopharmaceuticals, the Foundation for Barnes-Jewish Hospital and an anonymous foundation.<\/p>\n

GPS Tracking for Dementia and Alzheimer\u2019s Patients<\/strong><\/p>\n

If you or your loved one was recently diagnosed with dementia or Alzheimer\u2019s, a GPS tracking device<\/a> can help put your mind at ease. Please give us a call at LiveViewGPS and we can answer any and all of your questions. Call 1-888-544-0494<\/a>.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

A newer blood test for detecting brain changes indicative of early Alzheimer’s disease (AD) is becoming more realistic and could change everything for the field. Researchers of a study published in Neurology, found that assessing the \u03b2-amyloid (A\u03b2) 42 and A\u03b240 ratio in blood with the use of a high-accuracy evaluation is 94 percent accurate […]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_focus_keyword":"","rank_math_description":"","footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[11],"tags":[],"class_list":["post-6322","post","type-post","status-publish","format-standard","hentry","category-applications"],"yoast_head":"\nNew Blood Test for Alzheimers Has 94% Accuracy<\/title>\n<meta name=\"description\" content=\"Read the LiveViewGPS blog 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